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EU funding (€2,814,491): Probing safety of nano-objects by defining immune responses of environmental organisms Hor 27 Aug 2015 EU Research and Innovation programme "Horizon"
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Probing safety of nano-objects by defining immune responses of environmental organisms
PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.
Funded Companies:
| Company name | Funding amount |
| Alta Ricerca E Sviluppo IN Biotecnologie Srlu | ? |
| AvantiCell Science Ltd. | €273,288 |
| Cardiff University | €273,288 |
| Consiglio Nazionale Delle Ricerche | €516,123 |
| Eberhard Karls Universitaet Tuebingen | €249,216 |
| Fundacio Institut Catala de Nanociencia i Nanotecnologia | €247,873 |
| Mikrobiologicky Ustav AV CR V.V.I | €232,422 |
| Paris-Lodron-Universitat Salzburg | €255,934 |
| UK Centre for Ecology & Hydrology | €159,418 |
| United Kingdom Research and Innovation | €113,870 |
| Universita Degli Studi Di Genova | €258,061 |
| Univerza V Ljubljani | €234,998 |
Source: https://cordis.europa.eu/project/id/671881
The filing refers to a past date, and does not necessarily reflect the current state. The latest known state is available on the following page: Alta Ricerca E Sviluppo IN Biotecnologie Srlu, Siena, Italy.