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EU funding (€7,988,083): Validation and Comparitive Multi-Omics Benchmarking of Fluid-Derived Volatilomics Biomarkers for the Prevention and Early detection of Schizophrenia Hor 16 Dec 2024 EU Research and Innovation programme "Horizon"
Overview
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Validation and Comparitive Multi-Omics Benchmarking of Fluid-Derived Volatilomics Biomarkers for the Prevention and Early detection of Schizophrenia
Schizophrenia (SZ) impacts around 1% of the global population, posing diagnostic challenges that lead to a misdiagnosis rate of 23-40%. The need for reliable biomarkers is crucial to improve early detection and treatment outcomes. VOLABIOS aims to revolutionize SZ management by harnessing innovative real-time and portable spectrograph technology to validate volatile organic compounds (VOCs) as non-invasive and cost-effective biomarkers detectable during the early stages of the disease. This entails extensive data analysis, prospective clinical studies involving 3,692 subjects across six centres, and a blind validation study with 1,000 subjects, focusing on longitudinal monitoring of at-risk individuals to identify early SZ transition. To further substantiate the efficacy of VOCs and gain profound insights, VOLABIOS will integrate VOC analysis with genomics, proteomics, and transcriptomics. This integration will be supported by a biobank comprising approximately 4,000 samples and a dataset consisting of 9 million records. By considering external and personal risk factors as well as biological responses, VOLABIOS aims to unravel intricate correlations that contribute to SZ development. This comprehensive approach will enhance prediction accuracy, facilitate early detection, and improve management strategies. Furthermore, VOLABIOS plans to explore the real-time effects of validated VOCs through controlled in-vivo experiments using animal models, providing valuable information about associated cellular and molecular pathways. VOLABIOS's endeavours to validate and establish EU-wide SZ diagnosis protocols are set to significantly enhance patient care and healthcare efficiency, marking a substantial step forward in addressing the complexities surrounding SZ.
Funded Companies:
| Company name | Funding amount |
| Ainigma Technologies | €302,250 |
| Betthera s.r.o. | €172,500 |
| Cubic Snail ΟΕ | €199,663 |
| Ethniko Kentro Erevnas Kai Technologikis Anaptyxis | €376,250 |
| Exus Software Monoprosopi Etairia Periorismenis Evthinis | €494,884 |
| Firalis | €920,625 |
| Firalis Molecular Precision SA | €0.00 |
| Fundacion para La Gestion de La Investigacion en Salud de Sevilla | €0.00 |
| Gesellschaft ZUR Forderung Empirisch Begrundeter Therapieansatze | €56,975 |
| Heinrich-Heine-Universitaet Duesseldorf | €402,184 |
| Lietuvos Sveikatos Mokslu Universitetas | €350,028 |
| Servicio Andaluz de Salud | €564,082 |
| Smart Nano Sense Ltd. | €545,525 |
| Technion - Israel Institute OF Technology | €1,350,544 |
| Technion Research AND Development Foundation Ltd. | €0.00 |
| The Chancellor Masters and Scholars of the University of Cambridge | €477,503 |
| Timelex | €296,750 |
| Universidad de La Rioja | €0.00 |
| Universidade de Coimbra | €257,531 |
| Universitaetsklinikum Aachen | €833,040 |
| Ypourgeio Ygeias | €99,375 |
| Zentrum FUR Soziale Innovation GmbH | €288,375 |
Source: https://cordis.europa.eu/project/id/101156162
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