European Companies Search Engine
UK funding (£189,943): Spontaneously Biotinylated Lentiviral Vectors For Envelope Independent Targeting Of Infection Ukri18 Apr 2006 UK Research and Innovation, United Kingdom
Overview
Text
Spontaneously Biotinylated Lentiviral Vectors For Envelope Independent Targeting Of Infection
| Abstract | As a result of a BBSRC funded project we have generated a new 293T based cell line specifically for the production of metabolically biotin labelled lentiviral vectors. These bio-lentiviral vectors have been demonstrated to efficiently complex with streptavidin paramagnetic particles. This combination has resulted in the most efficient purification and concentration method yet described for lentiviral vectors. We wish to use the platform of these new biotin-lentiviral packaging cells to exemplify their value to the gene therapy community. By virtue of their biotinylated surface these viruses can be attached to specific cell binding proteins so that they can be targeted to specific sites of disease. Their unique properties also allow us to increase our knowledge of the cell derived accessory proteins that are also resident on the lentiviral surface. Information on the influence of these proteins on the process of lentiviral infection can then be applied to more efficient targeting of gene therapy vectors to specific sites of infection. |
| Category | Research Grant |
| Reference | BB/D007933/1 |
| Status | Closed |
| Funded period start | 18/04/2006 |
| Funded period end | 17/04/2009 |
| Funded value | £189,943.00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FD007933%2F1 |
Participating Organisations
| University of Cambridge |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University of Cambridge, Cambridge.
