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UK funding (£188,497): Transition state analysis to guide drug discovery. Ukri 1 Apr 2020 UK Research and Innovation, United Kingdom
Overview
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Transition state analysis to guide drug discovery.
| Abstract | There is an urgent need to find better methods to discover drugs. A third of clinical drugs target G-protein-coupled receptors (GPCRs). When a GPCR is activated by a drug, it changes its structural shape (conformation). Activation proceeds via a series of structural intermediates. The pathway of intermediate conformations dictates the intracellular signalling pathway activated by the drug:receptor complex. Currently it is not possible to predict if a drug will signal (efficacy) and by which pathway (signalling bias). We have developed a computational approach (Transistion State Analysis) that models intermediate conformational states as receptors are activated. Our method accurately predicted efficacy and bias of drugs at two GPCRs. Prior to commercialisation, we need to validate our methods using a wider range of therapeutic targets and drugs. This technology will accelerate drug discovery, saving time and money, and have significant end-user impact. |
| Category | Research Grant |
| Reference | BB/T004088/1 |
| Status | Closed |
| Funded period start | 01/04/2020 |
| Funded period end | 30/06/2022 |
| Funded value | £188,497.00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FT004088%2F1 |
Participating Organisations
| COVENTRY UNIVERSITY |
The filing refers to a past date, and does not necessarily reflect the current state. The latest known state is available on the following page: Coventry University UNIVERSITY, Coventry.