| Abstract |
Understanding the lubrication mechanism in healthy synovial joints such as hips and knees is important for not only understanding how these natural bearings operate in the human body but also developing intervention therapies. The unique load bearing material of articular cartilage in synovial joints is porous and elastic filled with water. Under loading, the interstitial water flows and supports a large percentage of external loading. The aims of this proposal are to develop and apply an advanced high resolution MRI to the lubrication studies of articular cartilage. The main objectives include the development of the MRI imaging methodology and design and development of a small scale experimental lubrication rig to be used inside the MRI to measure deformation, friction and wear. Once these methodologies are developed, applications will be made on both normal and degenerated tissues. Understanding the fluid flow and lubricating capacity for healthy and degenerated cartilage specimens in a range of loading conditions is important as cartilage substitution interventions and tissue engineering therapies are being developed. The outcome from the proposed research will provide timely guidelines for pre-clinical evaluation of these treatment options, and provide knowledge for the regulatory and standards bodies. This will have tremendous economic benefits to the UK NHS as well as clinical benefits to patients. |
