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UK funding (£88,229): Enzyme co-localisation and aggregation for enhanced metabolic activity for commodity chemicals. Ukri1 Sept 2016 UK Research and Innovation, United Kingdom
Overview
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Enzyme co-localisation and aggregation for enhanced metabolic activity for commodity chemicals.
| Abstract | Current approaches for enhancing bio-based commodity production are restricted to known biosynthetic pathways and limitations to metabolite toxicity. However, many key bio-commodities are made via aldehyde-intermediates such as acetaldehyde, lactaldehyde and propanaldehyde and their production is often limited because of the inherent toxicity of their chemical reactivity. Ways to reduce this toxicity would offer a significant advantage to the commercial production of these materials. This application outlines a major new strategy to reduce the toxicity of key metabolic intermediates such as acetaldehyde through the deployment of proteinaceous scaffolds. This approach will be coupled to a novel pathway that will be engineered in specific bacteria called acetogens that can live on gaseous exhaust fumes in order to produce a key chemical commodity called 1,3-butanediol. |
| Category | Feasibility Studies |
| Reference | 132326 |
| Status | Closed |
| Funded period start | 01/09/2016 |
| Funded period end | 30/11/2017 |
| Funded value | £88,229.00 |
| Source | https://gtr.ukri.org/projects?ref=132326 |
Participating Organisations
| ZUVASYNTHA LIMITED |
£88,229.00 |
| UNIVERSITY OF KENT |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Zuvasyntha Ltd., Knebworth.
