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UK funding (£377,536): Quantitative and contextual modelling of transcriptional responses to auxin Ukri 2 Jun 2008 UK Research and Innovation, United Kingdom
Overview
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Quantitative and contextual modelling of transcriptional responses to auxin
| Abstract | Auxin is a plant hormone that plays an important role in many, very different aspects of plant growth and development. For example, on one hand auxin regulates the pattern in which leaves emerge from the growing shoot tip, while on the other it mediates environmental responses such as the bending growth observed in shoots growing towards a light source. Because auxin is integral to so much of plant development, a knowledge of how auxin works is absolutely fundamental to our ability both to understand how plants grow and to improve important crop traits. Although it is unclear how auxin, a small and simple molecule, is able to regulate such a diversity of processes, it is known that changes in gene expression are important and that several hundred genes are either turned on or off in response to auxin. Work from several labs has established a network of signalling proteins whose complex interactions translate increases in auxin levels within a cell into gene expression changes. However, this model of auxin signalling is generic and contains several gaps which mean that in most cases it offers only a theoretical basis for understanding how auxin operates throughout the plant. We can identify the new information required to remedy this situation and with this work we intend to use newly available techniques to obtain these data and correct the deficiencies of the current model. The complexity of the interactions in this auxin response system mean that the data that describe it are similarly complex, and therefore we need to adopt a new approach for analysing the information that we will gather in which we build mathematical models that describe the functioning of the system. These models can then be used to test our predictions of how the auxin response system works, generate new hypotheses about its functioning, and ultimately tell us if we have understood its essential details. This higher level of understanding of auxin action will be useful to a number of groups, including plant biologists, crop scientists, and scientists studying similarly complex signalling mechanisms in other organisms. |
| Category | Research Grant |
| Reference | BB/F007418/1 |
| Status | Closed |
| Funded period start | 02/06/2008 |
| Funded period end | 01/11/2011 |
| Funded value | £377,536.00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FF007418%2F1 |
Participating Organisations
| University of Leeds | |
| UNIVERSITY OF NOTTINGHAM | |
| École normale supérieure de Lyon (ENS Lyon) | |
| University of California, San Diego (UCSD) | |
| Wageningen University & Research |
The filing refers to a past date, and does not necessarily reflect the current state. The latest known state is available on the following page: University of Leeds, LS2 9JT Leeds.
