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UK funding (£371,564): JPND TRanslating Individual Alzheimer GEnetic risk into disease phenotypes Ukri 1 May 2020 UK Research and Innovation, United Kingdom
Overview
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JPND TRanslating Individual Alzheimer GEnetic risk into disease phenotypes
| Abstract | By sequencing the genome of an individual, we can calculate a measure called a polygenic risk score (PRS). This is a single number that represents the risk that that individual has for developing a particular disease, such as Alzheimer's disease. We will be creating PRSs for two groups of individuals - one group from a memory clinic, and one group who have a high genetic risk for developing Alzheimer's disease. We will then take some cell samples from a subset of those individuals and turn them into pluripotent cells - cells which have the potential to become any other type of cell. We will differentiate these cells into microglia, which are a type of cell found between neurons in the brain. Microglia have recently been linked to the development of Alzheimer's disease. We can take these microglia and look at how they behave when transplanted into mice, and when interacting with simple brain models called organoids. From this we can learn how the PRSs we have calculated are linked to the way that microglia behave in the brain. This will teach us about how risk for developing Alzheimer's disease translates into the behavior of cells in the brain. This has the potential to point us towards new interventions and medicines for Alzheimer's patients, and will provide new information for researchers developing clinical trials. |
| Category | Research Grant |
| Reference | MR/T04604X/1 |
| Status | Closed |
| Funded period start | 01/05/2020 |
| Funded period end | 31/10/2023 |
| Funded value | £371,564.00 |
| Source | https://gtr.ukri.org/projects?ref=MR%2FT04604X%2F1 |
Participating Organisations
| CARDIFF UNIVERSITY | |
| University of Cambridge | |
| Catalan Health Institute (ICS) | |
| University of Lille | |
| UNIVERSITY OF OXFORD | |
| University of Leuven | |
| The Hong Kong University of Science and Technology | |
| German Centre for Neurodegenerative Diseases | |
| University of Glasgow | |
| University of California, Irvine | |
| Stanford University | |
| UNIVERSITY OF EDINBURGH | |
| Harvard University | |
| University of Liege | |
| National Institutes of Health (NIH) |
The filing refers to a past date, and does not necessarily reflect the current state. The latest known state is available on the following page: Cardiff University, Cardiff.