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EU funding (€1,786,748): Energy transduction in KInetically asymmetric catalytic NETworks Hor1 Sept 2022 EU Research and Innovation programme "Horizon"
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Energy transduction in KInetically asymmetric catalytic NETworks
Endergonic processes are central to Life. They are achieved by enzymes, that change conformation during their catalytic cycle. Thus, biological non-equilibrium processes are catalysis-driven. The realization of catalysis-driven processes in artificial systems proved challenging. It remains limited to synthetically demanding interlocked structures, which were upgraded with catalytic features affecting ring sliding motion. With KI-NET, I want to develop a general biomimetic strategy enabling endergonic processes driven by chemical catalysis. I plan to invert the current approach by introducing defined conformational freedom into simple catalytic units. KI-NET scientific objectives go beyond state of the art in chemically-driven non-equilibrium systems, with the aim to: (i) establish an unconventional theoretical approach based on “effective transition states”, that guides experiments and reveals common underlying principles for catalysis-driven processes and chemical oscillations; (ii) realize endergonic conformation changes powered by catalytic processes, including ATP hydrolysis; (iii) promote endergonic assembly reactions, that will reveal how energy consumption directs chemical adaptation; (iv) realize an artificial synthase: a catalyst that harvests energy from one reaction and uses it to drive a different one. I will implement a theory-guided experimental approach at the interface between systems chemistry and molecular machines. Leveraging my broad chemistry background, I will address questions that expand towards physics – in terms of formalizing models – and biology – in terms of operating systems to be imitated and unraveled. Realizing KI-NET allows overcoming thermodynamic boundaries. Unforeseen opportunities become possible in material science and energy management, such as the realization of artificial mitochondria. Indeed, KI-NET pioneers a largely unexplored area of science at the roots of dissipative systems, complex phenomena, and –ultimately, Life.
Funded Companies:
| Company name | Funding amount |
| Centre International de Recherche aux Frontieres de la Chimie Fondation | €1,786,748 |
| Universite de Strasbourg | €0.00 |
Source: https://cordis.europa.eu/project/id/101041933
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