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EU funding (€12.1M): REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT Hor17 Nov 2023 EU Research and Innovation programme "Horizon"
Overview
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REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT
Alzheimer's disease (AD), the main cause of dementia, is one of the major global health challenges of our time. This disabling disorder affects 55 million people worldwide, with costs above $1.3 trillion. With 67 million people at risk for AD dementia (prodromal and preclinical AD) in Europe alone, it is a major unmet public health need, with increasing burden for European economies, healthcare and social care systems and a concern for the future. Yet, prevention and early detection strategies have been lacking. Recent advances in disease-modifying therapies and the huge potential benefits of preventive multidomain interventions based on modifiable lifestyle and vascular factors (prevention potential ~ 40%) provide new opportunities. New developments in blood-based biomarkers (BBMs) and digital cognitive tests enable broader, cost-effective testing. The AD-RIDDLE platform is envisioned to revolutionize how AD is detected and diagnosed, prevented and treated across healthcare settings (HCS). AD-RIDDLE centres around a toolbox platform concept, providing a series of validated tools at each key step to enable HCS and practitioners to deploy enhanced AD management across diverse patient populations. The AD-RIDDLE toolbox platform will include a) community outreach tools to increase awareness/activation on AD prevention; b) combination of easily available, clinically validated biomarkers: digital cognitive tools and BBMs, for early detection of AD dementia risk; c) validated algorithms supporting clinical decisions, to identify people who can benefit from specific preventive therapies (pharma and/or non-pharma) using precision prevention approach. The toolbox usability and efficacy with be tested in real-world settings. We expect that the AD-RIDDLE modular and flexible design can facilitate broad uptake from different healthcare systems, and its tools can advance research to develop cost-effective preventive therapies for AD, with scalability for other dementias
Funded Companies:
| Company name | Funding amount |
| Imperial College of Science Technology and Medicine | ? |
| ALZHEIMER'S DISEASE INTERNATIONAL THE INTERNATIONAL FEDERATION OF ALZHEIMER'S DISEASE AND RELATED DISORDERS SOCIETIES Inc. | €157,000 |
| Alzheimer Europe | €538,000 |
| C2N DIAGNOSTICS LLC | €0.00 |
| Cambridge Cognition Ltd. | €0.00 |
| COMBINOSTICS Oy | €0.00 |
| DAVOS ALZHEIMER'S COLLABORATIVE | €0.00 |
| DAVOS ALZHEIMER'S COLLABORATIVE | €0.00 |
| Fujirebio Europe N.V. | €0.00 |
| Fundacio Barcelonabeta Brain Research Center | €1,038,000 |
| GATES VENTURES LLC | €0.00 |
| Goeteborgs Universitet | €738,500 |
| ITA-SUOMEN YLIOPISTO | €929,000 |
| Karolinska Institutet | €734,250 |
| Lunds Universitet | €1,095,250 |
| NEOTIV GmbH | €0.00 |
| Region Stockholm | €2,932,750 |
| Sanofi-Aventis Recherche & Developpement | €0.00 |
| STICHTING AMSTERDAM UMC | €1,121,250 |
| Stiftelsen Fingers Brain Health Institute | €590,250 |
| Synapse Research Management Partners SL | €803,250 |
| Universita Degli Studi Di Perugia | €519,000 |
| UNIVERSITEIT MAASTRICHT | €537,000 |
| Vastra Gotalandsregionen | €356,750 |
Source: https://cordis.europa.eu/project/id/101132933
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Imperial College of Science Technology and Medicine, London.
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