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EU funding (€1,999,633): A data-driven computational framework to discover how behavior impacts processing in mouse visual cortex Hor11 Jul 2025 EU Research and Innovation programme "Horizon"
Overview
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A data-driven computational framework to discover how behavior impacts processing in mouse visual cortex
Our movements influence how we perceive the world. Our eyes are attached to a behaving body creating a complex dynamical stream of input that can provide additional information if we know the movement pattern. The interaction between motor and visual signals is especially pronounced in rodent visual cortex that exhibits a substantial, multi-dimensional contribution from motor signals, even in early visual areas. However, a fundamental principle that governs the interaction between visual and motor signals across neurons and visual areas is currently unknown, especially for freely moving animals. I hypothesize that the interaction between visual and motor tuning in mouse visual cortex provide the animal with a consistent and behaviorally beneficial multi-modal picture of its environment. However, studying the interaction between motor behavior and sensory processing is challenging as experiments face a trade-off between experimental control in head-fixed animals (but limited movement) and the availability of rich movement signals in freely moving animals (but limited experimental control). I propose that this trade-off can be bridged by a data-driven in silico neuroscience approach that compiles experimental data into a digital twin that captures the interaction between physiology, motor behavior, internal state, and a model of the environment. The goal of this proposal is to build such an in silico framework to capture the detailed influence of motor behavior on visual processing in freely behaving mice. I will use this framework to discover fundamental organizational principles of the relation between visual and motor tuning across neurons and areas in mouse visual cortex, use them to test computational theories, and develop computational models to quantify their behavioral benefit. This project will not only change our view on the influence of motor signals in visual cortex, but also yield a computational framework with countless applications in neuroscience.
Funded Companies:
| Company name | Funding amount |
| GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS | €1,450,783 |
| UNIVERSITATSKLINIKUM BONN | €548,850 |
Source: https://cordis.europa.eu/project/id/101171526
The filing refers to a past date, and does not necessarily reflect the current state.
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