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UK funding (£223,744): Networks top down; Signal transduction in and between proteins Ukri1 Sept 2006 UK Research and Innovation, United Kingdom
Overview
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Networks top down; Signal transduction in and between proteins
| Abstract | Macromolecular interactions such as protein-protein interactions are crucial for most biological processes. Tens of thousands of proteins and other macromolecules are expressed in a typical cell, mediating thousands of physical interactions at a given moment, either to form molecular machines or to participate in various regulatory processes. It is essential to understand how these interactions are organized and how signals can be transmitted between the macromolecules, because failure in interaction and signalling could lead to diseases or even death. In the research project I propose, the network and dynamics of interactions in and between proteins are investigated by computational methods to elucidate possible mechanisms of intra and intermolecular signal transmission. I want to determine how signals can be propagated within and between proteins. To do so, temporal and spatial changes in the interaction network will be analysed in detail. This analysis will help to develop possible models for signal transmission in and between macromolecules. It will improve our understanding of how living organism can process and store information, as well as make decisions which is crucial for their survival. Furthermore, it will increase our capability to intervene specifically in biological processes and prevent failures in signal transmission which could be linked to disease. |
| Category | Fellowship |
| Reference | G0600158/1 |
| Status | Closed |
| Funded period start | 01/09/2006 |
| Funded period end | 31/08/2009 |
| Funded value | £223,744.00 |
| Source | https://gtr.ukri.org/projects?ref=G0600158%2F1 |
Participating Organisations
| University of Cambridge |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University of Cambridge, Cambridge.
