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EU funding (€7,787,818): Sustainable Exploitation of bio-based Compounds Revealed and Engineered from naTural sources. Hor 21 May 2021 EU Research and Innovation programme "Horizon"
Overview
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Sustainable Exploitation of bio-based Compounds Revealed and Engineered from naTural sources.
SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes.
Funded Companies:
| Company name | Funding amount |
| Accuplex Diagnostics Ltd. | €321,875 |
| Bio Base Europe Pilot Plant VZW | €758,125 |
| Blue Synergy SL | €313,500 |
| Eberhard Karls Universitaet Tuebingen | €498,250 |
| Ethniko Kai Kapodistriako Panepistimio Athinon | €546,500 |
| Exelisis ΙΚΕ | €377,000 |
| Idener Research & Development AIE | €933,750 |
| Imperial College of Science Technology and Medicine | €472,320 |
| Lunds Universitet | €541,250 |
| Matis OHF | €605,063 |
| Pharma Mar SA | €334,730 |
| Sphera Encapsulation Srl | €480,454 |
| Stazione Zoologica Anton Dohrn | €408,375 |
| Sylentis SA | €579,112 |
| Universidad de Sevilla | €617,515 |
Source: https://cordis.europa.eu/project/id/101000794
The filing refers to a past date, and does not necessarily reflect the current state.
