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Managing Director: Thomas Ernst Gauch · No longer Managing Director (3) · Share­holder agreement · Name: Chiesi Orphan GmbH Hrb7 Aug 2017 German Trade Register Announcements, Germany

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HRB 129308: Horizon Pharma Germany GmbH, Ungenannte Str. ??, 60325 Frankfurt a. Main, Germany. The Shareholders' Meeting of July 19, 2017 decided to amend the partnership agreement in section 1 (a) and with it to amend the company. New company: Chiesi Orphan GmbH. Retired Managing Director: Federer, Richard Eric, Dublin/ Ireland, *??.??.????; Kelly, David, Sandycove/ Ireland, *??.??.????. Appointed Managing Director: Gauch, Thomas Ernst, Hamburg, *??.??.????, authorised to represent in accordance with general representation rules; with the power to enter into legal transactions on behalf of the company a.s. a representative of a third party. Retired and reappointed: Managing Director: Hecken-Meißner, Gerald, St. Augustine, *??.??.????, authorised to represent in accordance with general representation rules.

This filing was translated from German to English. The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Chiesi Orphan GmbH, Frankfurt a. Main, Germany.

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