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EU funding (€3,455,309): Organoid technologies for disease modeling, drug discovery and development for rare diseases Hor24 Jul 2023 EU Research and Innovation programme "Horizon"
Overview
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Organoid technologies for disease modeling, drug discovery and development for rare diseases
The vast majority of rare diseases are characterized by genetic origin, often severe in pathology and with limited or no treatment options. This also includes the paediatric disorders cystic fibrosis (CF) and cystinosis. Both diseases usually manifest in the first year of life. In recent year, great progress has been made in CF research allowing a swift transfer of novel drugs from bench to bedside. This is fueled by the application of advanced in vitro models, viz. organoids, in phenotyping patients and personalize treatment options. In ORGESTRA, we propose to use stem cell-derived organoids to train 13 Doctoral Candidates (DCs) in developing personalized disease models for the lung and kidney diseases, CF and cystinosis, with significant unmet clinical needs. Research will aim to identify pathogenetic mechanisms and druggable targets, drug mode of action for effective and innovative treatment strategies, classify the pathway to clinic and address ethical and regulatory issues to foster acceptance and implementation of the organoid models. Eventually, a living technologies toolset will be developed for a swift transfer from bench to bedside. ORGESTRA will provide an international, intersectoral and interdisciplinary training by creating a new expert framework of 14 partners from 7 countries, combining molecular biologists, engineers, pharmacologists, clinicians, epidemiologists and ethicists, giving each DC unique, joint-doctoral training and tailored experience in industry and/or patient organisations, complemented with a rich workshop programme. The ORGESTRA objectives contribute perfectly to the Horizon Europe goals of the societal challenge on improving the health and well-being of the EU citizens.
Funded Companies:
| Company name | Funding amount |
| Astrazeneca AB | ? |
| Fciencias.ID - Associação para A Investigacao e Desenvolvimento de Ciencias | €486,806 |
| Instituto de Biologia Experimental e Tecnologica | €243,403 |
| Katholieke Universiteit Leuven | €787,860 |
| MERCURNA B.V. | €274,370 |
| UNIVERSITAIR MEDISCH CENTRUM UTRECHT | €548,741 |
| UNIVERSITEIT UTRECHT | €548,741 |
| Universite Paris Cite | €565,387 |
Source: https://cordis.europa.eu/project/id/101120108
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: AstraZeneca AB, Södertälje, Sweden.
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