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EU funding (€8,925,241): Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes Hor1 Nov 2022 EU Research and Innovation programme "Horizon"
Overview
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Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes
HappyMums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy, and the efficacy of interventions. It will interrogate a large collection of cohorts with multiple biological, medical, clinical, socio-demographic and environmental and lifestyle data to identify the most robust risk factors triggering depressive symptoms, but also moderators of the risk. By putting together unique human samples of placenta, chorionic villi and amniotic fluid, and animal models, HappyMums will improve the understanding of the neurobiological mechanisms affected by depressive symptoms in pregnancy that lead to alterations in the foetal environment, shaping offspring risk for developing negative mental outcomes. The use of three complimentary rodent models will allow to achieve a proof of causality, and the presence of an innovative fish model will elucidate the mechanisms specific to placenta by which adverse maternal conditions are transmitted to the offspring without the potentially confounding mitigating effects of compensatory postnatal maternal care. This knowledge will allow the identification of new targets for the development of novel medications, for the repurposing of existing medications or for the development of non-pharmacological interventions. HappyMums will also develop a digital platform where AI tools-based data can be collected, together with biological, clinical, medical, environmental and lifestyle data, through a mobile phone App that will be at the interface with clinicians via a dedicated dashboard. This will allow early screening of depressive symptoms, prompt diagnoses, personalized treatments, and the promotion of protective lifestyle attitudes. Overall, HappyMums will not only increase the knowledge in the field of mental disorders in pregnancy, but also improve the wellbeing of these women, providing unprecedented benefits also to the offspring and thus to society at large.
Funded Companies:
| Company name | Funding amount |
| King's College London | ? |
| Aarhus Universitet | €467,812 |
| AB.Acus Srl | €560,975 |
| CHARITE - UNIVERSITAETSMEDIZIN BERLIN | €700,976 |
| ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | €1,392,533 |
| HELSINGIN YLIOPISTO | €676,152 |
| HRVATSKO KATOLICKO SVEUCILISTE | €323,250 |
| Ospedale SAN Raffaele Srl | €650,575 |
| Societa Marce Italiana Per LA Salute Mentale Perinatale | €89,462 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | €449,375 |
| Universita Degli Studi Di Milano | €1,620,416 |
| Universitat de Barcelona | €938,306 |
| UNIVERSITEIT VAN AMSTERDAM | €328,851 |
| Uniwersytet SWPS | €246,312 |
| WAGENINGEN UNIVERSITY | €480,246 |
Source: https://cordis.europa.eu/project/id/101057390
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: King's College London UNIVERSITY, London.
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