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EU funding (€2,809,260): First Closed-loop non-Invasive Seizure Prevention System Hor24 Feb 2023 EU Research and Innovation programme "Horizon"
Overview
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First Closed-loop non-Invasive Seizure Prevention System
The goal of Project RELIEVE is to build the very first non-invasive effective closed-loop monitoring and intervention system for brain-related disorders. The outcomes can be used to treat or manage various psychiatric and neurological disorders. We do this by pushing the technological boundaries in two separate domains. (1) AI domain: We develop a class of mathematical and algorithmic tools for brain data based on the recently developed mathematical theories that are potentially useful for the real-time monitoring of the brain data. Such advancements have shown promise in robotics and self-driving cars and have high potential to work efficiently in highly dynamic environments where personalization and low computation power is a must. This makes such algorithms runnable using brain data such as EEG (electric activity on the head surface) on ordinary wearable devices. (2) Neurostimulation domain: We combine two characteristics of the ultrasound waves in stimulation and imaging of the nervous system to build the first smart-navigated wearable ultrasound patch. We also choose the vagus nerve as the target for neurostimulation as one of the most promising sites to interact with the nervous system with proven implications for a large spectrum of neurological and psychiatric disorders (e.g. dementia, depression, epilepsy, etc.). We call this unit 'WU-VNS' standing for non-invasive wearable ultrasound vagus nerve stimulation. In the next three years, we will use epilepsy as the first use case of the developed technologies to train and test a closed-loop system. For this, the AI monitors the brain through a patch that records EEG in addition to other physiological measures such as heart rate and motion. Upon prediction of a forthcoming anomaly (seizure in this case) by the AI unit, the neurostimulation module activates and stimulates the vagus nerve non-invasively. During this process also a so-called 'active learning' happens in which the AI learns from the reactions of the nervous system to the stimulation protocol and can fine-tune the protocol for future interventions. To achieve this, we have designed a complex phase-based development and testing plan: The first two generations (Gen. 1 and 2) are the intermediate versions of the full system and act in open loops validating each of the AI and neurostimulation subsystems. These two generations already have high potentials to independently turn into medical device products with large market needs. Ultimately, in Gen. 3 we close the loop by integrating the AI and the WU-VNS and consequently validate the efficacy and the usability of the system.
Funded Companies:
| Company name | Funding amount |
| CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS | ? |
| ALPHA BRAIN TECHNOLOGIES | €665,435 |
| Irccs - Associazione LA Nostra Famiglia 'Istituto Scientifico Eugenio Medea' | €291,750 |
| Masarykova Univerzita | €357,125 |
| STICHTING EPILEPSIE INSTELLINGEN NEDERLAND | €220,000 |
| STICHTING KEMPENHAEGHE | €220,000 |
| TECHNISCHE UNIVERSITEIT DELFT | €672,450 |
| Universiteit Gent | €382,500 |
Source: https://cordis.europa.eu/project/id/101099481
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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