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UK funding (£999,394): Macrophages and diabetic nephropathy Ukri29 Jan 2007 UK Research and Innovation, United Kingdom
Overview
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Macrophages and diabetic nephropathy
| Abstract | Despite improvements in medical care, the incidence of diabetic kidney disease has rapidly increased and it is now the most common cause of kidney failure, necessitating dialysis or transplantation. It is therefore important that we identify novel treatments to prevent or retard the development of kidney disease in individuals with diabetes. Recent research indicates that chronic inflammation is an important feature of diabetic kidney disease and key inflammatory cells called macrophages are implicated in progression of the disease. The current research will examine whether kidney disease in diabetic mice can be prevented by administration of a toxin that specifically kills macrophages. In addition, as macrophages localise to injured kidneys, diabetic rats will be injected with genetically-modified macrophages that will deliver protective mediators specifically to the damaged kidneys. Finally, tissue culture experiments will be employed to determine how the abnormal proteins that accumulate in diabetic renal disease alter both pro-inflammatory and anti-inflammatory macrophage functions. By understanding the inflammatory pathways involved in diabetic kidney damage, we may be able to develop novel treatments. |
| Category | Fellowship |
| Reference | G0501900/1 |
| Status | Closed |
| Funded period start | 29/01/2007 |
| Funded period end | 28/01/2011 |
| Funded value | £999,394.00 |
| Source | https://gtr.ukri.org/projects?ref=G0501900%2F1 |
Participating Organisations
| University of Edinburgh |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University OF Edinburgh CHARITY, Edinburgh.
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