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EU funding (€3,263,726): Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits Hor15 Sept 2022 EU Research and Innovation programme "Horizon"
Overview
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Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits
Separating enantiomers is crucial to produce bio-active molecules, e.g., in early-phase drug discovery. CHIRALFORCE aims at a radically new strategy to separate enantiometers on chip, using chiral optical forces at silicon-based integrated waveguides. The present solution of chiral chromatography for this multi-billion market is slow and cumbersome since it requires tailored chemistry for each chiral compound, and relies on large and expensive separation columns. Instead, CHIRALFORCE envisions cm-length optical circuits integrated with microfluidics for extremely quick, tuneable, and cheap enantiomeric separation. The underlying mechanism relies on optical forces that are enantioselective, due to interaction of spin-properties of the optical field with the chiral optical polarizability of matter. These chiral optical forces can be tailored well beyond the possibilities of free-space chiral light through nanophotonic design of strongly confined modes. Flowing analyte in microfluidic channels along cm-length laser-driven will then result in enantio-separation. The approach to reach our main objectives relies on three main consortium strengths. First, we will design and synthesize chiral molecules and nanoparticles that will allow us to explore chiral forces regardless of how the chiral polarizability of matter is tuned by the size, shape, and in-built spectroscopic resonances, Next, we will establish the general framework of chiral optical forces on nanoparticles and molecules in liquid environments, leveraging our strength in nanophotonic theory, design and experiment, on chiral/spin-properties of electromagnetic fields. Finally, we will leverage our experience in nanotechnology to fabricate silicon-based photonic integrated circuits integrated with microfluidics to demonstrate enantiomer separation.
Funded Companies:
| Company name | Funding amount |
| King's College London | ? |
| STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN | €1,010,000 |
| SYMERES NETHERLANDS B.V. | €358,750 |
| TALLINNA TEHNIKAÜLIKOOL | €459,631 |
| Universita Degli Studi Di Milano | €225,845 |
| Universitat Politecnica de Valencia | €757,250 |
| UNIVERSITEIT TWENTE | €452,250 |
Source: https://cordis.europa.eu/project/id/101046961
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: King's College London UNIVERSITY, London.
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