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EU funding (€2,805,404): PRInted Symbiotic Materials as a dynamic platform for Living Tissues production Hor23 Aug 2022 EU Research and Innovation programme "Horizon"
Overview
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PRInted Symbiotic Materials as a dynamic platform for Living Tissues production
The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials. We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched with engineered helper cells (either bacteria or yeasts, depending on the application and requirements). Tuning the operational parameters of the bioprinting process, we will cast down the material controlling the mechanical properties of each voxel, to get to a 3D patterned structure where stem cells are locally induced to initiate their differentiation towards different lineages. As far as stem cells proliferate, the helpers remain in a quiescent state. However, when the stem cells get stimulated by the local (printed) mechanics and enter a differentiation pathway, they start secreting a pool of lineage-specific metabolites. The helper cells are designed to sense these early markers of differentiation, and to respond by producing in-situ the corresponding growth factors, providing the relevant chemical guidance. Helper cells within the platform amplify the initial lineage commitment in each area and dynamically sustain differentiation on a longer term. During the project we will implement this strategy and develop two independent symbiotic materials, targeting biomedical and food applications, respectively.
Funded Companies:
| Company name | Funding amount |
| University of Glasgow | ? |
| Cellink Bioprinting AB | €729,375 |
| Chalmers Tekniska Hogskola AB | €698,375 |
| IN Srl Impresa Sociale | €479,061 |
| STICHTING RADBOUD UNIVERSITEIT | €449,500 |
| Universidade de Aveiro | €449,093 |
Source: https://cordis.europa.eu/project/id/101070913
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University of Glasgow Court, Glasgow.
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