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UK funding (£970,479): Elucidation of the mechanism of bone marrow failure in acute myeloid leukaemia Ukri4 Sept 2006 UK Research and Innovation, United Kingdom
Overview
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Elucidation of the mechanism of bone marrow failure in acute myeloid leukaemia
| Abstract | Leukaemia is a type of bone marrow cancer. Leukaemia prevents the bone marrow from doing its job, that is to make healthy blood cells. These blood cells include red cells that carry the oxygen round the body, white cells that fight infection and platelets that help the blood clot. Patients with leukaemia suffer from a deficiency of these cells and consequently become breathless or tired (low red cell numbers), are vulnerable to severe infection (low white blood cell numbers) and bleed spontaneously (low platelet numbers). Although we can replace the red cells by blood transfusion it is not possible to replace platelets and white blood cells effectively. Therefore patients with leukaemia frequently develop infections and bleeding, and many die from these complications. The cells in the normal bone marrow that make all the blood cells are called stem cells. These stem cells are present in patients with leukaemia but appear to be prevented from working by the leukaemia. The aim of this project is to find out how the leukaemia stops the stem cells from working. By understanding how leukaemia inhibits stem cells we hope to be able to develop treatments to overcome this problem. |
| Category | Fellowship |
| Reference | G0501940/1 |
| Status | Closed |
| Funded period start | 04/09/2006 |
| Funded period end | 03/01/2011 |
| Funded value | £970,479.00 |
| Source | https://gtr.ukri.org/projects?ref=G0501940%2F1 |
Participating Organisations
| Queen Mary University of London |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Queen Mary University of London, London.
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