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EU funding (€148,636): REGULATORY T CELLS AND TISSUE DAMAGE CONTROL Hor3 May 2016 EU Research and Innovation programme "Horizon"
Overview
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REGULATORY T CELLS AND TISSUE DAMAGE CONTROL
Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage imposed by inflammation and immunity. The central hypothesis to be tested under this proposal is that tissue-resident TREG modulate tissue damage control via a number of adaptive responses to cellular stress, which preserve the functional outputs of parenchyma tissues. Failure of tissue-resident TREG to modulate adaptive responses to oxidative and hypoxic stress should exacerbate the deleterious effects imposed by these forms of stress on parenchyma cells and as such promote the pathogenesis of immune mediated inflammatory diseases. Under this Marie-Curie fellowship we will address mechanistically how TREG receive signals from tissues exposed to oxidative and hypoxic stress and migrate to those tissues to modulate oxidative and hypoxic stress responses as to dampen tissue damage.
Funded Companies:
| Company name | Funding amount |
| Fundacao Calouste Gulbenkian | €148,636 |
Source: https://cordis.europa.eu/project/id/707998
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Fundação Calouste Gulbenkian, Lisbon, Portugal.
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