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UK funding (£190,255): Differential effects of methicillin-resistant and methicillin-sensitive Staphylococcus aureus on nasal and pulmonary inn Ukri1 Feb 2007 UK Research and Innovation, United Kingdom
Overview
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Differential effects of methicillin-resistant and methicillin-sensitive Staphylococcus aureus on nasal and pulmonary inn
| Abstract | ‘Superbugs‘ (bacteria capable of evading antibiotics) continue to increase steadily in hospitals and in the community. The superbug associated with the greatest public notoriety and clinical significance is methicillin-resistant Staphylococcus aureus (MRSA). MRSA can cause devastating pneumonia and septicaemia. These complications are inevitably preceded by a period of ‘colonisation‘, referring to a state where the MRSA lives in selected sites (eg the nose) without causing clinical illness. This stimulates the intriguing question of why the nose tolerates MRSA while the lung responds with exuberant inflammatory responses. My application will test the hypothesis that the nose tolerates MRSA because (relative to the lung) it is deficient in molecules (called Toll-like receptors) that recognise bacteria on human cells, and because MRSA specifically switches off production of antibacterial molecules in the nose. These studies are likely to improve significantly understanding of how different parts of the body react to bacteria. In addition, the lining of the nose cannot ‘eat‘ (and therefore clear) MRSA efficiently. The second part of my project will involve transferring ‘eating‘ genes to nasal cells in the lab and observing clearance of MRSA. This novel gene therapy approach represents a potential future treatment for colonisation and infection caused by MRSA. |
| Category | Fellowship |
| Reference | G0600457/1 |
| Status | Closed |
| Funded period start | 01/02/2007 |
| Funded period end | 31/01/2010 |
| Funded value | £190,255.00 |
| Source | https://gtr.ukri.org/projects?ref=G0600457%2F1 |
Participating Organisations
| University of Edinburgh |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University OF Edinburgh CHARITY, Edinburgh.
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