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UK funding (£467,162): Defining kisspeptin neuronal networks and function in the mouse hypothalamus (Resubmission). Ukri2 Jan 2013 UK Research and Innovation, United Kingdom
Overview
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Defining kisspeptin neuronal networks and function in the mouse hypothalamus (Resubmission).
| Abstract | Fertility in mammals is controlled by a small part of the brain called the hypothalamus. At puberty, a protein called kisspeptin initiates the release of a hormone called GnRH, which is required for normal growth of the genitalia and fertility. Kisspeptin is produced by nerves in two specific areas of the hypothalamus known as the AVPV and the ARC regions. This project will study the way in which kisspeptin producing neurons in these regions are connected to other parts of the brain. This will allow us to understand how the activity of kisspeptin neurons is controlled by signals from other regions of the brain. To do this, we will use a specialized virus that can only spread between neurons that are physically connected to each other. The virus will be activated in kisspeptin neurons and the movement of the virus tracked over time as it spreads to connected neurons. The identity of these neurons will be determined from their anatomical location and by looking at the chemical messengers (neurotransmitters) that they express. The functional significance of these connections will be determined by examining whether kisspeptin neurons can respond to these neurotransmitters. This project will provide us with fundamental knowledge about how fertility is regulated by hormonal changes and under different conditions such as day length, lactation and ageing. |
| Category | Research Grant |
| Reference | BB/K003178/1 |
| Status | Closed |
| Funded period start | 02/01/2013 |
| Funded period end | 01/01/2016 |
| Funded value | £467,162.00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FK003178%2F1 |
Participating Organisations
| University of Cambridge |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University of Cambridge, Cambridge.
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