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UK funding (£614,375): Biopharmaceutical HOS analysis by automated fast hydrogen deuterium exchange Ukri1 Sept 2016 UK Research and Innovation, United Kingdom
Overview
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Biopharmaceutical HOS analysis by automated fast hydrogen deuterium exchange
| Abstract | Knowledge of a biopharmaceutical product’s higher order structure (HOS) and conformational dynamics, and how these relate to it’s mode of action and/or degradation, are central to enable effective and streamlined biopharmaceutical development through QbD-based approaches. Hydrogen deuterium exchange mass spectrometry (HDX MS) is a technique increasingly used to characterise the HOS of peptide and protein therapeutics. HDX MS can determine structural perturbations in a protein that elicit changes in conformational dynamics or solvent accessibility. Commercial implementation of automated HDX MS analysis, has greatly increased the utility of HDX MS in the biopharmaceutical industry for HOS analysis. But there are limitations with these systems where unstructured or highly dynamic, solvent exposed protein regions are not able to be differentiated or analysed. This team propose to develop a system that will allow routine analyse of these proteins and peptides with HDX MS. |
| Category | Collaborative R&D |
| Reference | 102612 |
| Status | Closed |
| Funded period start | 01/09/2016 |
| Funded period end | 31/05/2019 |
| Funded value | £614,375.00 |
| Source | https://gtr.ukri.org/projects?ref=102612 |
Participating Organisations
| APPLIED PHOTOPHYSICS LIMITED |
£368,423.00 |
| CENTRE FOR PROCESS INNOVATION LIMITED |
£139,861.00 |
| UNIVERSITY OF EXETER |
£105,116.00 |
| UNIVERSITY OF CAMBRIDGE |
£975.00 |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: Applied Photophysics Ltd., Leatherhead.
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