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UK funding (£361,883): The Role of the RamA Locus in the Establishment of Antibiotic Resistance and its Potential for Novel Antibiotic Therapy Ukri1 Jul 2007 UK Research and Innovation, United Kingdom
Overview
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The Role of the RamA Locus in the Establishment of Antibiotic Resistance and its Potential for Novel Antibiotic Therapy
| Abstract | Klebsiella pneumoniae is a major hospital pathogen which causes a multitude of infections in both immuno-competent and compromised patients. The emergence of multidrug resistant K. pneumoniae has grave implications for public health as options with which to control these organisms are becoming scarce. Antibiotic resistance emerges when bacteria survive the initial drug challenge and undergo mutations. Certain proteins in bacteria facilitate the survival of bacteria under these conditions. One such protein made by K. pneumoniae is the RamA protein. RamA is a regulatory protein that controls genes involved in antibiotic resistance, fitness and virulence. This research aims to understand what role RamA plays in the bacterial cell in allowing survival and subsequent emergence of antibiotic resistance. Understanding of the role of RamA will give insights into strategies bacteria use to survive antibiotic challenge. This information is crucial in combating the emergence and spread of antibiotic resistance. |
| Category | Research Grant |
| Reference | G0601199/1 |
| Status | Closed |
| Funded period start | 01/07/2007 |
| Funded period end | 31/10/2010 |
| Funded value | £361,883.00 |
| Source | https://gtr.ukri.org/projects?ref=G0601199%2F1 |
Participating Organisations
| University of Edinburgh |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University OF Edinburgh CHARITY, Edinburgh.
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