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UK funding (£774,751): The role of ATP-binding cassette transporter A3 (ABCA3) in lung injury, repair and fibrosis Ukri15 Jan 2007 UK Research and Innovation, United Kingdom
Overview
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The role of ATP-binding cassette transporter A3 (ABCA3) in lung injury, repair and fibrosis
| Abstract | Acute Respiratory Distress Syndrome (ARDS) is an acute, severe injury to the lungs which is caused by a variety of diseases including trauma, shock and severe infections. Patients are very unwell and often require mechanical ventilation in intensive care units. There are no particularly effective treatments of ARDS which is fatal in 30 to 40% of patients. It is not fully understood how ARDS develops though it may be related to the loss or malfunction of the normal lung protective mechanisms. Surfactant is a compound which normally acts as a lubricant within the lungs, though it also helps to protect the lungs against injury and infection. Patients with ARDS have been shown to have a deficiency in surfactant. Furthermore, abnormal surfactant production, often due to gene mutations, has been associated with lung injury in infants and adults. We therefore believe that the absence or mutation of ABCA3, a new gene recently associated with surfactant synthesis, will make the lungs more vulnerable to injury and therefore ARDS. We aim to demonstrate this with scientific models, in which the ABCA3 gene is manipulated, and by identifying ABCA3 mutations in patients with ARDS. Such studies could generate potential future treatment options. |
| Category | Fellowship |
| Reference | G0501950/1 |
| Status | Closed |
| Funded period start | 15/01/2007 |
| Funded period end | 14/10/2011 |
| Funded value | £774,751.00 |
| Source | https://gtr.ukri.org/projects?ref=G0501950%2F1 |
Participating Organisations
| University of Edinburgh |
The filing refers to a past date, and does not necessarily reflect the current state. The current state is available on the following page: University OF Edinburgh CHARITY, Edinburgh.
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