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UK funding (£175,153): Defining the role of Filaggrin in skin barrier function and eczema. Ukri1 Nov 2007 UK Research and Innovation, United Kingdom
Overview
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Defining the role of Filaggrin in skin barrier function and eczema.
| Abstract | Eczema is a very common disease, causing a red, itchy rash and affecting more than 1 in 5 people. Its cause is poorly understood, but a recent finding is that about half of eczema patients have a deficiency in the gene which makes filaggrin. All patients with a related condition, ichthyosis vulgaris have these gene changes, but they do not have inflamed skin. Filaggrin is a protein that plays an important part in forming the protective barrier at the outer layer of the skin. These data suggests that an underlying cause of eczema is a defective skin barrier, which allows substances to enter the skin and spark of an immune reaction and the classic itchy red rash. Over half of eczema patients apparently have normal filaggrin however. I will test this theory by measuring the skin barrier function in eczema patients with normal and abnormal filaggrin and see if they differ. I will see how icthyosis and eczema patients differ and whether there is a difference between patients with ‘allergic‘ (atopic) and non-allergic eczema. If patients with an apparently normal filaggrin gene have a defective skin barrier, I will find out if there are unidentified abnormalities in filaggrin or other skin barrier proteins. |
| Category | Fellowship |
| Reference | G0700507/1 |
| Status | Closed |
| Funded period start | 01/11/2007 |
| Funded period end | 31/10/2010 |
| Funded value | £175,153.00 |
| Source | https://gtr.ukri.org/projects?ref=G0700507%2F1 |
Participating Organisations
| University of Edinburgh |
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